General James "Mad Dog" Mattis has been nominated to be the Secretary of Defense.
- Secretary of Defense
- Deputy Secretary of Defense
- Director – Operational Test and Evaluation
- General Counsel
- Inspector General
- Assistant Secretary for Legislative Affairs
- Under Secretary for Acquisition, Technology and Logistics
- Principal Deputy Under Secretary of Defense for Acquisition, Technology and Logistics
- Deputy Under Secretary for Logistics and Materiel Readiness
- Deputy Under Secretary for Acquisition and Technology
- Assistant to the Secretary for Nuclear and Chemical and Biological Defense Programs
- Director of Defense Research and Engineering
- Under Secretary (Comptroller) and Chief Financial Officer
- Under Secretary for Intelligence
- Under Secretary for Personnel and Readiness
- Principal Deputy Under Secretary for Personnel and Readiness
- Assistant Secretary for Health Affairs
- 9 Members of the Uniformed Services University of the Health Sciences Board of Regents (six-year terms of office)
- Assistant Secretary for Reserve Affairs
- Under Secretary for Policy
- Principal Deputy Under Secretary for Policy
- Assistant Secretary for Asian and Pacific Security Affairs
- Assistant Secretary for Global Security Affairs
- Assistant Secretary for Homeland Defense
- Assistant Secretary for International Security Affairs
- Assistant Secretary for Special Operations/Low Intensity Conflict & Interdependent Capabilities
- Secretary
- Under Secretary
- Assistant Secretary for Acquisition, Logistics, and Technology
- Assistant Secretary for Civil Works
- Assistant Secretary for Financial Management and Comptroller
- Assistant Secretary for Installations, Energy and Environment
- Assistant Secretary for Manpower and Reserve Affairs
- General Counsel
- Chief of Staff (four-year term of office)
- Secretary
- Under Secretary
- Assistant Secretary for Financial Management and Comptroller
- Assistant Secretary for Installations and Environment
- Assistant Secretary for Manpower and Reserve Affairs
- Assistant Secretary for Research, Development, and Acquisition
- General Counsel
- Chief of Naval Operations (four-year term of office)
- Commandant of the Marine Corps (four-year term of office)
- Joint Chiefs of Staff
- Chairman of the Joint Chiefs of Staff (two-year term of office)
- Vice Chairman of the Joint Chiefs of Staff (two-year term of office)
- Under Secretary of Energy for Nuclear Security/Administrator of the National Nuclear Security Administration
- Principal Deputy Administrator - National Nuclear Security Administration
- Deputy Administrator for Defense Programs - National Nuclear Security Administration
- Deputy Administrator for Defense Nuclear Nonproliferation - National Nuclear Security Administration
- Assistant Secretary for Environmental Management